Basophil Competence during Hookworm (Necator americanus) Infection
نویسندگان
چکیده
منابع مشابه
Necator americanus (human hookworm) aspartyl proteinases and digestion of skin macromolecules during skin penetration.
The infective larvae of Necator americanus were shown to secrete all mechanistic classes of proteolytic enzymes with two overall pH optima of 6.5 and 8.5 using fluorescein isothiocyanate-labeled casein as the substrate. Since infective larvae are obligate skin penetrators, the effect of each of these enzyme classes against macromolecules derived from human skin was examined. Larval secretions w...
متن کاملStage-specific immune responses in human Necator americanus infection
We describe how hookworms interact with their human hosts by comparing lymphocyte phenotyping, proliferative responses, and cytokine and chemokine secretion patterns in adults who are either mono-infected with Necator americanus or egg-negative controls resident in an area of high transmission in Brazil. Cellular immune responses against crude hookworm antigen extracts from different developmen...
متن کاملProteolytic degradation of hemoglobin in the intestine of the human hookworm Necator americanus.
Blood-feeding parasites use mechanistically distinct proteases to digest hemoglobin (Hb), often as multienzyme cooperative cascades. We investigated the roles played by 3 distinct proteases from adults of the human hookworm Necator americanus. The aspartic protease Na-APR-1 and the cysteine protease Na-CP-3 were expressed in catalytically active form in yeast, and the metalloprotease Na-MEP-1 w...
متن کاملPotential Transmission of Pathogens Between Human Hosts by the Hookworm, Necator Americanus
Experimental trials are underway exploring the use of parasitic helminthes to treat autoimmune diseases. As with any experimental therapy, such trials must adequately address safety concerns associated with the treatment protocol. In the treatment protocol employed by Autoimmune Therapies, patients are inoculated intradermally with the common nematode hookworm Necator Americanus. Beyond the pot...
متن کاملNecator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses
BACKGROUND Helminth co-infection in humans is common in tropical regions of the world where transmission of soil-transmitted helminths such as Ascaris lumbricoides, Trichuris trichiura, and the hookworms Necator americanus and Ancylostoma duodenale as well as other helminths such as Schistosoma mansoni often occur simultaneously. METHODOLOGY We investigated whether co-infection with another h...
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ژورنال
عنوان ژورنال: The American Journal of Tropical Medicine and Hygiene
سال: 2007
ISSN: 0002-9637,1476-1645
DOI: 10.4269/ajtmh.2007.77.860